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Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes. Redox Biol. 2024 Sep;75:103253.
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Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2024 Jun 13;67(11):9194-9213.
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Autophagy is essential for human myelopoiesis. Stem Cell Reports. 2024 Feb 13;19：1-15.
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补充描述
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Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation. Cell Stem Cell. 2023 September 7; 30:1235-1245.
关键技术支撑：病理技术、病理图片采集分析
技术支撑成果
Shan Y, Zhang Y, Wei Y, Zhang C, Lin H, He J, Wang J, Guo W, Li H, Chen Q, Zhou T, Xing Q, Liu Y, Chen J, Pan G. METTL3/METTL14 maintain human nucleoli integrity by mediating SUV39H1/H2 degradation. Nat Commun. 2024 Aug 21;15(1):7186.
Yang L, Ruan Z, Lin X, Wang H, Xin Y, Tang H, Hu Z, Zhou Y, Wu Y, Wang J, Qin D, Lu G, Loomes KM, Chan WY, Liu X. NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nat Commun. 2024 Jan 16;15(1):546.
Zhang C, Shan Y, Lin H, Zhang Y, Xing Q, Zhu J, Zhou T, Lin A, Chen Q, Wang J, Pan G. HBO1 determines SMAD action in pluripotency and mesendoderm specification. Nucleic Acids Res. 2024 May 22;52(9):4935-4949.
Wu T, Hu J, Zhao X, Zhang C, Dong R, Hu Q, Xu H, Shen H, Zhang X, Zhang Y, Lin B, Wu X, Xiang Q, Xu Y. Discovery of a Promising CBP/p300 Degrader XYD129 for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2024 Jun 13;67(11):9194-9213. doi: 10.1021/acs.jmedchem.4c00335. Epub 2024 Jun 3. PMID: 38829718.
Chen X, Huang X, Ma Q, Kuzmič P, Zhou B, Zhang S, Chen J, Xu J, Liu B, Jiang H, Zhang W, Yang C, Wu S, Huang J, Li H, Long C, Zhao X, Xu H, Sheng Y, Guo Y, Niu C, Xue L, Xu Y, Liu J, Zhang T, Spencer J, Zhu Z, Deng W, Chen X, Chen SH, Zhong N, Xiong X, Yang Z. Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nat Microbiol. 2024 Apr;9(4):1075-1088.
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Cui Y, Yuan T, Wang Y, Zheng D, Qin L, Li S, Jiang Z, Lin S, Guo W, Wang Z, Liang Z, Li Y, Yao Y, Liu X, Tang Q, Tu HY, Zhang XC, Tang Z, Wong N, Zhang Z, Qin D, Thiery JP, Xu K, Li P. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity. Cell Rep. 2023 Jul 25;42(7):112797.
Zhang S, Zhai M, Xu Y, Han J, Chen J, Xiong Y, Pan S, Wang Q, Yu C, Rao Z, Sun Q, Sui Y, Fan K, Li H, Guo W, Liu C, Bai Y, Zhou J, Quan D, Zhang X. Decellularised spinal cord matrix manipulates glial niche into repairing phase via serglycin-mediated signalling pathway. Cell Prolif. 2023 Sep;56(9):e13429
Wu Y, Chen K, Li L, Hao Z, Wang T, Liu Y, Xing G, Liu Z, Li H, Yuan H, Lu J, Zhang C, Zhang J, Zhao D, Wang J, Nie J, Ye D, Pan G, Chan WY& Liu X. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death Differ. Published: 25 May 2022.
Li P, Wang Q, He Y, Yang C, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L, Chen L. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerg Microbes Infect. 2023 Dec;12(1):e2136538.
Chen M, Shi H, Gou S, Wang X, Li L, Jin Q, Wu H, Zhang H, Li Y, Wang L, Li H, Lin J, Guo W, Jiang Z, Yang X, Xu A, Zhu Y, Zhang C, Lai L, Li X. In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers. Genome Med. 2021 Apr 12;13(1):57.
Xu Y, Zhou J, Liu C, Zhang S, Gao F, Guo W, Sun X, Zhang C, Li H, Rao Z, Qiu S, Zhu Q, Liu X, Guo X, Shao Z, Bai Y, Zhang X, Quan D. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials. 2021 Jan;268:120596.
Wang Q, Xiong Y, Zhang S, Sui Y, Yu C, Liu P, Li H, Guo W, Gao Y, Przepiorski A, Davidson AJ, Guo M, Zhang X. The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics Approach. Front Genet. 2021 Feb 10;12:632810.
Guo W, Wang Q, Pan S, Li J, Wang Y, Shu Y, Chen J, Wang Q, Zhang S, Zhang X, Yue J. The ERK1/2-ATG13-FIP200 signaling cascade is required for autophagy induction to protect renal cells from hypoglycemia-induced cell death. J Cell Physiol. 2021 Oct;236(10):6932-6947.
Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B,Li W, Zeng M, Li C, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D. SS18 is a critical regulator at the pluripotent-somatic interface. Nat Commun. 2021 Jul 2;12(1):4090.
Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan WY, Liu J, Chen Y, Li P, Liu X. Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nat Struct Mol Biol. 2021 Nov;28(11):900-908.
Xu X, Guo W (equal contribution), Pan S, Zhang Y, Gao F, Wang J, Zhang S, Li H, Wang R, Zhang X. TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer. Aging (Albany NY). 2020 Oct 8;12(19):19335-19351.
