1.开发基于溶酶体靶向嵌合体技术的蛋白质降解剂，为肿瘤治疗提供新思路
论文发表相关信息：
Lysosome Targeting Chimaeras for Glut1-Facilitated Targeted Protein Degradation,J. Am. Chem. Soc. 2024, 146, 17728−17737
关键技术支撑：MALDI质谱表征、核磁结构表征、流式分析
2.研发一种可降解乳酸-乙醇酸（PLGA）结合黑磷（BP）的高分子多功能仿生多孔支架，研究黑磷支架在植入骨组织中引起的免疫响应功能。证明黑磷具有调控巨噬细胞极化及对骨免疫微环境和骨再生的调节作用。
论文发表相关信息：
Regulation of Osteoimmune Microenvironment and Osteogenesis by 3D-Printed PLAG/black Phosphorus Scaffolds for Bone Regeneration, Advanced Science, 2023, 10, 2302539
关键技术支撑：扫描电镜成像技术、元素分析技术、流式分析
3.构建横跨18个发育阶段、19种组织的人类胚胎免疫系统发育高分辨率图谱。对类小胶质细胞的多器官分布、促血管生成巨噬细胞的分子、功能和空间特征等细胞群特征进行分析，完成人类胚胎免疫系统发育高分辨率图谱的构建。
论文发表相关信息：
An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development,Cell ，2023，186, 4454–4471
关键技术支撑：流式细胞分选和分析
4.开展二氧化碳还原合成葡萄糖和脂肪酸研究，通过电催化将二氧化碳和水合成高纯乙酸，再以乙酸及乙酸盐为碳源经生物发酵合成葡萄糖和脂肪酸等长碳链分子。该科研成果入选2022年国内十大科技新闻。
论文发表相关信息：
Upcycling CO2 into energy-rich long-chain products via electrochemical and metabolic engineering,Nature Catalysis,2022,5, 388–396
关键技术支撑：透射电镜成像技术
5.开发黑磷二维纳米材料作为一种新型MALDI基质，集成微通道技术发展成质谱检测新方法，快速检测微升级血液样本中的磷脂酰胆碱（PC）和溶血磷脂酰胆碱（LPC）类脂质。相比于常规MALDI基质，纳米黑磷基质可以提升PC和LPC类脂质检测的灵敏度（10倍以上）和重复性；并有效降低基质杂峰对脂质检测的干扰。黑磷纳米基质辅助激光解析电离质谱（BPALDI-MS）成功检测哮喘和支气管肺炎儿童血清中PC和LPC类脂质，是黑磷材料和微通道技术的MALDI-MS在临床分析领域的新应用，有望为体液中疾病标志物检测的方法开发提供借鉴指导
论文发表相关信息：
Detection of serum phospholipids by microchannel-integrated black phosphorus-assisted laser desorption/ionization mass spectrometry,Talanta,Volume 237, 15 January 2022, 122978
关键技术支撑：质谱成像技术
6.利用生物成像平台的联影磁共振成像系统，基于国际前沿的波浪鸡尾酒（Wave-CAIPI）快速三维成像技术，在国际上率先提出了一套快速有效的波浪（Wave）梯度参数优化方案；针对波浪梯度所存在的梯度零阶矩不为“零”这一关键问题，在国际上首次提出了一种新的截断式波浪梯度，不仅完善了磁共振快速三维成像理论基础，同时进一步推动了相关的高级磁共振快速三维成像技术走向临床应用
论文发表相关信息：
Parameter optimization framework on wave gradients of Wave-CAIPI imaging,Magnetic Resonance in Medicine,2020,Volume83,Issue5,Page1659-1672
关键技术支撑：磁共振成像技术
技术支撑成果
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